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In women, this ceruloplasmin deficiency may be aggravated during menopause, where decreased estrogen causes decreased ceruloplasmin synthesis [356]

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A substantial proportion of these compounds are lipophilic in nature and exhibit extremely low solubility in the aqueous environment of the gastrointestinal tract

Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen species (ROS), is recommended as an effective clinical antidote against APAP-induced acute liver injury (AILI) when it is given at an early phase