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In addition, a therapeutic nanovaccine (NV) mediated by CuS-R848 coated with HA can significantly inhibit tumors and prevent tumor recurrence and metastasis by inducing immunogenic cell death (ICD) and DCs maturation (104)

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Differential diagnosis: Hepatocellular necrosis resulting from direct toxicity may have a diffuse or lobular distribution but also may be accompanied by infarction