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J Cell Sci (2010) 123:4195200

Similarly, MYC binds directly to the promoter elements of glutamine transporters such as ASCT2 and SN2 in T cells to promote their mRNA synthesis, thereby increasing glutamine uptake and metabolism and supporting the activation and functional maintenance of immune cells [17]

The progression of AD is associated with BBB dysfunction, even at an early stage (216, 217)

Furthermore, the gut microbiota can modulate the HPA axis by increasing gut barrier permeability or inducing pro-inflammatory states

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