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Description
However, it is also seen among non-athletes, caused by repetitive strains on the knee during everyday activities such as climbing stairs or sitting for prolonged periods with the knees bent

Backeljauw, P
doi:10.1111/j.1469-1809.2009.00551.x

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Many companies find it helpful to use audit management software to keep track of CAPA tasks, keep good records, and have everything ready if the FDA asks for proof that the fixes were made and are effective

For Phase 0 it is not needed that your IND is filed, submitted, and approved by the FDA
