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In vitro , 5-amino-1MQ significantly reduced intracellular MNA, increased intracellular NAD + , and suppressed lipogenesis in adipocytes
Bioorganic & medicinal chemistry letters
Importantly, NNMTi is highly selective and has no inhibitory effect on other SAM-dependent methyltransferases or NAD + salvage pathway enzymes
Mechanisms and inhibitors of nicotinamide N-methyltransferase
doi: 10.1021/acscombsci.0c00077
SAM is involved in hundreds of methylation reactions throughout the body, and the systemic effects of preserving SAM through NNMT inhibition in tissues beyond adipose tissue remain unknown
