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Bacteria produce endotoxins such as lipopolysaccharide (LPS) that activate iNOS in macrophages

doi: 10.3389/fncel.2025.1588645 Received 06 March 2025 Accepted 14 April 2025 Published 20 May 2025 Volume 19 - 2025 Edited by Neville Ng, University of Wollongong, Australia Reviewed by Mingzi Zhang, University of Southern California, United States Slawomir Jakiela, Warsaw University of Life Sciences, Poland Vasileios Balis, Aegean College, Greece Updates Copyright 2025 Liu, Sun, Guo, Yuan, Zhu, Lu, Chen, Qu, Feng and Yang

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Lipid-soluble antioxidants such as resveratrol and vitamin E and the decrease in iron-mediated ROS via NAC and overexpression of superoxide dismutase 2 (SOD2) attenuated autophagy [96, 109, 110]

These tumors exhibit dependencies on serine hydroxymethyltransferase (SHMT)-mediated pathways that represent novel therapeutic vulnerabilities [64, 65]

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