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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

Oral or parenteral therapy for B12 deficiency

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Most patients begin noticing changes within 46 weeks, with more visible results after 812 weeks

The individuals sustained the weight loss for over two years