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62,63,64,65,66 However, the exact role of astrocytes in BBB function is still controversial

Acta Histochemica

Competing interests The authors declare that the review was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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In addition, there is a higher intensity of CD38 expression (measured by flow cytometry) in the more aggressive multi-hit variants, which allows further differentiation of the diseases and the use of CD38 as a biomarker for early diagnosis [14]