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44(2): 30111 Acknowledgements The authors have provided no information on sources of funding or on conflicts of interest directly relevant to the content of this study

Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism

Schedule: Weekly subcutaneous injections for 12+ weeks with gradual dose escalation

Interestingly, there is a mutual relation between oxidative stress and obesity, as abnormal fat accumulation can stimulate a pro-inflammatory and a pro-oxidant state through various biochemical and cellular mechanisms (2426)

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This redox interaction supports deactivation of CBC enzymes and activation of the first step of the oxidative pentose phosphate pathway, respectively, facilitating the tight regulation of plastid carbon metabolism in light to dark transitions to avoid futile cycling