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This feature is tightly related to the fact that they are spots where ROS are produced and are especially vulnerable to the damage they cause (Bhatt et al., 2021)

Two wheat glutathione peroxidase genes whose products are located in chloroplasts improve salt and H 2 O 2 tolerances in arabidopsis

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In T cells of SLE patients, mTOR activation triggers ROS production, while SIRT2 concurrently upregulates IL-17A expression in these cells by modulating the mTOR complex 1 (mTORC1)/HIF-1/RORt signaling pathway, thereby contributing to the pathogenesis of SLE (101, 155)