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Interventions can be incorporated when symptoms do not respond fully to conservative measures

This is a risk/reward calculation that should be approached cautiously

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However, the effect of C677T polymorphisms of MTHFR on cognitive function was not significant in normal subjects as a longitudinal cognitive study showed that the MTHFR C677T polymorphism was not associated with cognitive performance at baseline or over 12 years 49

[DOI] [PubMed] [Google Scholar] 148.Kryscio R.J., Abner E.L., Schmitt F.A., Goodman P.J., Mendiondo M., Caban-Holt A., Dennis B.C., Mathews M., Klein E.A., Crowley J.J

doi: 10.1074/jbc.M002725200