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Experimental findings further revealed that increased expression of fructose-metabolizing enzymes and fructose exposure in cardiomyocytes promoted glycolytic activity and lipid accumulation, strongly suggesting a direct role of the polyol pathway in diabetic cardiac dysfunction [24]

doi: 10.1016/j.ymthe.2017.11.009 245 ChenJYeZHuangCQiuMSongDLiYet al

Substantial evidence indicates a strong negative crosstalk between the HPA axis and the HPG axis (126)

doi: 10.5115/acb.22.222 101 WuHZhangYLiYSunSZhangJXieQet al

When an area of the body has poor circulation ~ like tendons and ligaments ~ increased blood flow may support healing

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