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Nowadays, ROS production has also been observed in a variety of cells other than phagocytes, and their implication in physiologic signaling is well documented ( The Role of Lifestyle in Oxidative Stress Response Lifestyle: smoking, alcohol consumption, adequate or inappropriate diet, exercise, training or untrained condition, contribute to oxidative stress

PLoS One 11 (12), e0168907

Altering the PUFA composition of dopaminergic neuronal membranes and co-treating with iron can synergistically amplify lipid peroxidation and trigger ferroptosis, which has been confirmed in LUHMES cell and mouse organotypic brain slice experiments (70)

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