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Model and physiological GSSR substrates are, for example, l-cysteine-glutathione disulfide (GSSCys) 915 , coenzyme A-glutathione disulfide 3,16 , as well as S -glutathionylated serum albumin 9,11,1720 , sirtuin 21 , sulfiredoxin 22 , and peroxiredoxins 2329

It is among the most clinically evidenced brightening actives for post-inflammatory and UV-induced hyperpigmentation

Despite this, efficacy limitations in long-term weight-loss trials meant that AOD 9604 was not developed as an approved drug

The pathway of systemic and tissue level oxidative stress in these diseases is complex leading to inflammation and subsequent effects on vascular remodelling, endothelial function and mitochondrial dysfunction [6,7]

Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation

doi: 10.1002/cne.23355