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On the other hand, it is interesting to note that the two ZafA-binding motifs in the gliA promoter are located 130 and 183 bp upstream of the binding site for the GipA C 2 H 2 transcription factor (positioned at 316 bp upstream of the gliA TSC) ( gliA and gliP expression in the presence of GliZ, whereas only the induction of gliA by GliZ depends on GipA, which led the authors to hypothesize that GliZ and GipA worked together at the same binding site ( gliA promoter lacks of an obvious GliZ binding motif, the correlation between gliZ expression and gliotoxin biosynthesis, the essential role of ZafA for gliA expression during zinc starvation and the close proximity of the ZafA and GipA binding sites in the gliA promoter, it would appear more feasible that GipA, whose activity could also be influenced by the intracellular amount of gliotoxin, plays a role as a modulator of the ZafA-mediated induction of gliA under zinc starvation to adjust the gliA expression level to the intracellular amount of gliotoxin

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For example, Soinio et al

Should you take a selenium supplement

Tissue Eng Regener Med

Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease