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Description
- January 30, 2023
10.1038/s41598-019-40833-x 54 SheyR

p16 INK4a is a cell cycle inhibitor that blocks CDK4/6 activity, preventing cells from progressing from the G1 phase to the S phase of the cell cycle

The anti-CD70 monoclonal antibody cusatuzumab can disrupt the positive feedback loop and reverse resistance to anti-PD-1 therapy, providing a new strategy for the treatment of PTC and ATC [100]

Translation to human disease states, definitive molecular targets, doseresponse relationships, and standardized clinical endpoints remain inadequately characterized in the peerreviewed clinical literature
[DOI] [PubMed] [Google Scholar] 19.Guesnet P, Alessandri JM
