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To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms ( NSAIDs, Paracetamol, and COVID-19 In March 2020, ibuprofen and NSAIDs were discouraged because of the alert by Micallef et al

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The chemical messenger, or neurotransmitter, provides a way to send the signal across the extracellular space, from the presynaptic neuron to the postsynaptic cell

Supplementary information Supplementary Figures 1-8 and Supplementary Tables 1-2 (PDF 813 kb) Supplementary Data 1 (download XLSX Organisms in the microbiota model (XLSX 15 kb) Supplementary Data 2 (download XLSX Reactions of the microbiota metabolic network (XLSX 101 kb) Rights and permissions About this article Cite this article Sridharan, G., Choi, K., Klemashevich, C