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Given the importance of mTOR in CD8+ T cells, clinical research on its role in CD8+ T cells remain lacking

Pramar YV, Moniz D

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doi: 10.1007/s00406-012-0302-2

Teplizumab: a disease-modifying therapy for type 1 diabetes that preserves beta-cell function

cruzi skews macrophage polarization toward regulatory profiles, the impairment of dendritic cell maturation and Th1 induction, resistance to and subversion of complement pathways, expansion of myeloid-derived suppressor cells (MDSCs), and suppression and delay of adaptive immunity by driving non-specific B-cell activation, thymic atrophy, and T-cell dysfunction