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Available online: [DOI] [PubMed] [Google Scholar] 126.Thapa D., Cairns E.A., Szczesniak A.-M., Toguri J.T., Caldwell M.D., Kelly M.E.M

Although the plasma halflife is 913 hours, clinical effects may persist for 35 days.41 Significant inhibitors (eg, grapefruit juice, clarithromycin) and inducers (eg, enzalutamide, topiramate) of CYP3A4 system increase and decrease levels, respectively, and are to be avoided if possible.42 Caution is recommended in patients with severe liver disease

Curcumin also induced a reduction in plasma concentrations of inflammatory markers and an increase in plasma concentrations of brain-derived neurotrophic factor compared to placebo (antidepressant drug alone) (104)

& Lyssiotis, C

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