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The compound appears well-tolerated in animals at doses well above those producing metabolic effects
In Caco-2 intestinal epithelial cells, butyrate shows high responsiveness by activating the Nrf2 pathway

Similarly, in laryngeal cancer, GPx1 upregulation was associated with lymph node metastasis and cancer stage and was an independent predictor of patient survival (HR, 2.101, 95%CI, 1.0114.367) [137]
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
