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the signal molecules (mTOR, PI3K/Akt, AMPK, Nrf-2/HO-1, HIF-1, Notch, RhoA and GSK-3)

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Non-covalent small-molecule Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) inhibitors and their potential for targeting central nervous system diseases

NNMT inhibition may actually improve the adipocytes capacity to oxidize fat by restoring the NAD+-dependent sirtuin activity and mitochondrial function that fatty acid oxidation requires

doi: 10.3390/ijms21030859 64 BagchiSHeYZhangHCaoLVan RhijnIMoodyDBet al

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