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In addition, SD rats were dosed orally for 2 years at 10, 20, 40, and 60 mg/kg/day (3 to 19 times the oral MRHD based on mg/m2)

At the PEN stage, expression levels of PDX1, CDX2, and SOX9 were increased by 66%, 20%, and 61%, respectively, and HHEX levels remained lower by 24% in GPX2 KO cells compared with WT (Fig

Icterus and evidence of hepatic dysfunction suggests a more serious, potentially fatal hepatopathy, requiring discontinuation of medication and symptomatic and supportive care

DOI:10.1186/s12876-021-01614-x 72

Pt and its prodrugs could be conjugated on the surface of inorganic NPs, for instance, via the chemical reaction between specific functional groups (e.g., NH 2 and COOH) (Yang et al., 2019)