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This AA-PE intermediate is further oxidized by ALOX enzymes, resulting in the generation of lipid hydroperoxides and the eventual induction of ferroptosis [96]
doi: 10.3389/fnins.2019.00859
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For example, Liu et al

Among patients with CRC, 10% exhibited a partial response, 80% achieved stable disease, and 10% experienced disease progression 97

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria