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The gut microbiota colonizes and reproduces on intestinal epithelial surfaces, secreting enzymes that catalyze carbohydrate and metabolize indigestible carbohydrates into gut metabolites, vitamins, and some neurochemicals (15)

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HDAC6 inhibitor Ricoliostat: HDAC6 inhibitors can promote the degradation of protein aggregates or protect neurons from oxidative stress, hence can be used as possible drugs for treating peripheral neuropathy