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Cyclic ADP-ribose and NAADP in vascular regulation and diseases

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I., Metwally, M., Arisha, A

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By triggering NLRP3 activation in human induced pluripotent stem cells (iPSC)-derived microglia through TLR2 engagement and mitochondrial damage, -synuclein species have been shown to directly contribute to innate immunological activation in PD [56, 57]