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Research on the symptoms and pathophysiological mechanisms involved in COVID-19 provides strong evidence for oxidative stress, hyper inflammation, and brain alterations underlying glial activation and neuroinflammation from COVID-19 in triggering and exacerbating MDD

Proteasomes play a crucial role in the degradation of oxidized and ubiquitinated proteins, thus maintaining protein homeostasis and ensuring an adequate cellular stress response

Cell 172 , 135146 e139 (2018)

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