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Indeed, PV levels are known to change in an activity-dependent manner 40 , and lower PV levels suggest reduced firing of these interneurons

J Pharmacol Exp Ther 382:223232 Rudnick G, Krmer R, Blakely RD, Murphy DL, Verrey F (2014) The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

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Bioorg Chem 143:106963

Other reported side effects have been mild muscle fatigue or feeling chilled during a long infusion, which likewise tend to subside afterward

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