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Mini Rev Med Chem 2021, 21 (19), 30303036

While following L-carnitine oral challenge, E4-TR mice had higher increases in the L-carnitine metabolites, GBB and crotonobetaine in the brain and a reduction of plasma to brain total acylcarnitine ratios compared to other genotypes

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Deoxycholic acid (D-6750), inactin (T133), horse serum (H1138), and Triton X-100 were purchased from Sigma-Aldrich

Although the effectiveness of diosmin for treating RLS has not been tested, it remains a promising possible treatment