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While more human trials are needed to further explore this topic, one study showed depleted levels of glutathione in the hippocampus of generally healthy elderly persons, resulting in mild cognitive impairment, a precursor to more advanced impairment down the road

Genes (Basel) 12(6):800 Muraki K, Nyhan K, Han L, Murnane JP (2012) Mechanisms of telomere loss and their consequences for chromosome instability

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Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis