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(3) Administration and Metabolism: Mirabegron is administered orally once daily (2550 mg) and undergoes hepatic metabolism via multiple pathways, including dealkylation and oxidation

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For deeper changes in skin tone or the reduction of dark spots, it may take 3 months or more of daily supplementation

Furthermore, the NF-B activation is related to impairing the epithelial barrier function by TJ disassembly