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Fatty acid oxidation was significantly increased in tumor cells living in an acidic TME (123)

Glutathione possesses a unique gamma-peptide bond between the gamma-carboxyl group of glutamate and the alpha-amino group of cysteine, conferring resistance to degradation by most intracellular peptidases while remaining susceptible to gamma-glutamyltransferase

High concentrations of intracellular glutathione act as a cysteine reservoir

Translocation of a gut pathobiont drives autoimmunity in mice and humans

Nuclear factor-kappa B (NF-kB) has a significant role in inflammation and cell growth, which are both connected to the development of tumors (170, 171)

10.1093/jac/dkr405 127 ShafeeqS.YesilkayaH.KloostermanT