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High-Dose Vitamin-C Enhances Cancer Immunotherapy Numerous tumors resist the immune response by expressing high amounts of checkpoint proteins, such as programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) [195]

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Fundam Clin Pharmacol (1993) 7(8):389400

Although the rectal route bypasses the respiratory tract, systemic effects could theoretically still occur, and patients with asthma should be monitored closely

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Ensure sufficient resources are available to maintain data quality and study integrity