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Phase 2b mechanistic-pharmacology study in CKD useful as an outside-T2DM endpoint reference for kidney-pharmacology researchers and as an example of how the multi-agonist mechanism is being investigated in non-obesity comorbid disease

Split dosing is unnecessary and suboptimal

Blocking NNMT raises cellular NAD+, which in research supports fat-cell metabolism and fat loss

In turn, stools may contain more bile, turning yellow

In case of an Adverse Analytical Finding (AAF) in-competition, the athlete may apply for a retroactive TUE as provided for in the applicable rules

For repeated measures data, two-way repeated measures ANOVA (2-way RM ANOVA) was employed