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However, older adults may exhibit depleted vitamin B12 stores[51] and may therefore be particularly susceptible to vitamin B12 deficiency even after a short-term period of metformin therapy

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Start with the guidelines in this article but closely observe how you feel and adjust accordingly

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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

Keep in mind that the kidneys are responsible for clearing MMA, so kidney disease can cause falsely high serum MMA levels or falsely low uMMA levels