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Some supplements like nicotinamide riboside and nicotinamide mononucleotide directly increase NAD+

Clinical relevance of MGMT in the treatment of cancer

783 Moreover, intracellularly accumulated F-1,6-BP can bind with HMGB1, decreasing the affinity of HMGB1 for DNA and DNA adducts and sensitizing cancer cells to DNA replication stress and damage induced by chemotherapeutic agents, thereby promoting cancer cell apoptosis

doi: 10.1016/j.canlet.2018.04.038 35 RenMZhaoLMaZAnHMarrinkSJSunF

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3335, dated 1st October 2022