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These multiprotein complexes play a pivotal role in orchestrating the inflammatory response by enabling caspase-1dependent activation of the potent pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18) upon detection of cellular danger signals (233)

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71 Agents such as 1-cyano-2-hydroxy-3-butene, present in cabbage, brussels sprouts, broccoli, and cauliflower, have raised GSH concentrations severalfold in animal models