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Description
APOE is also implicated in mitochondrial fatty acid (FA) metabolism

Nature Med.), which demonstrated that metabolism by intestinal microbiota of dietary L-carnitine produced trimethylamine N-oxide (TMAO) and accelerated atherosclerosis in mice

Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans
Nature News 2013-04-07, consult 2013-04-14 (en) Stanley L

It can be derived directly from L-arginine through the action of nitric oxide synthases resulting in nitric oxide production or via conversion by arginase into ornithine in the urea cycle to deliver L-citrulline [21, 132]
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