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Weakened tight junction increases the intestinal barrier permeability, which enables leaky gut effect, leading to increased levels of anti- Ruminococcus gnavus antibodies (anti-RG) that act on Ruminococcus gnavus (RG) antigens and worsen kidney damage in lupus patients (82)

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Expert Opin Investig Drugs 23(3):291294 Won H, Ryu H, Shin D, Yeon S, Lee DH, Kwon SH (2018) A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells

After 24 h adhesion, cells were pretreated (1 h) with lisinopril or PBS before plasmid transfection (1 g)