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ii) mitochondrial impairment leading to ROS accumulation

doi: 10.1177/0748233718758092 46 JiHWangDWuYNiuYJiaLLiuBet al

Mutations of optineurin in amyotrophic lateral sclerosis

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Indeed, BSO-induced cell death is achieved when cells are treated for 72 h or longer [29], whereas 24 h is sufficient to achieve cell death by Cyss deprivation