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Thus, when the original highly damaging electrophilicity of OH is buffered by H 2 and its target porphyrin, the electrophilicity provided by OH can indirectly activate Nrf2 to reduce oxidative stress

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However, both in vitro and in vivo experiments have shown that at high ethanol concentrations (above 20 mM), the rate stops being linear, with higher concentrations yielding larger increases

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NR has a substitution of a nitrogen in place of the 5 sulfur yielding a phenazine nucleus with side chains on the 3, 7 carbons