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Vitamin B-12 deficiency has the following pathomorphology and symptoms: [19] Pathomorphology includes: A spongiform state of neural tissue along with edema of fibers and deficiency of tissue
de novo methylation during development is also observed in DNMT3s DKO mESCs as well as in mouse early embryos deficient in both of DNMT3A and DNMT3B, which leads to embryonic lethality (Okano et al., 1999
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