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Ramzy EA (2017) Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study

This is the case for the majority of participants in the PROMINENT trial

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Blocking MR receptors and interfering with glucocorticoids stimulation of glutamate activity counteracted stress-induced suppression of the histone acetyltransferase p300 mRNA levels in the hippocampus, showing a link between glucocorticoids and epigenetic programming of the glutamatergic system [20]

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