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The concern originated from a misunderstood study about niacinamide conversion to niacin under very specific high-pH laboratory conditions that dont occur in typical skincare formulations or application scenarios

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On the other hand, primary hepatic cells exposed to CCl4 (4 mM) presented a significant reduction in cell viability when compared to the control group

Some researchers use 3.0mL for a more concentrated 26.7mg/mL solution
