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Since the main foci of this study are to explore and exemplify new diagnostic and therapeutic approaches to PTSD cases, a profound analysis of PTSD in terms of its biological, sociological, developmental, psychological, and even ontological aspects are provided by embracing the digital revolutions of the society with its novel implications and insights

The recently described constitutional mismatch repair syndrome may also be associated with hypo or hyperpigmented lesions, but in the latter case, they appear to have more irregular and diffuse borders than typical CaLS.39 Despite the rarity of this syndrome, its possibility should not be ignored, as patients are at high risk of tumors in the intestines and central nervous system, as well as hematological cancers in the early years of life, and up to 97% of the 34 patients in follow-up in an international consortium study had at least one CaLS since childhood.39 Finally, other genodermatoses indicated in the table may be associated with CaLS,12 but there are usually too few of them to meet the diagnostic criterion for NF1

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Quantification of bacterial urease activity To quantify remnant urease activity post-treatment, Berthelots method (Weatherburn, 1967) was adapted and slightly modified