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Description
Gabapentinoids Gabapentin and pregabalin undergo no hepatic metabolism and are renally excreted, making them appealing therapeutic options for patients with hepatic impairment [48]

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The thiol is deprotonated first, before reacting with H 2 O 2 , with the rate-determining transition state of the reaction being methanethiolate attack on H 2 O 2

2020;368:eaat5314

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