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The assay was measured by monitoring the increase in absorbance at 265 nm for 1 min owing to the reduction of DHA into AsA using an extinction coefficient of 14 mM 1 cm 1
At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )

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Biotechnol Bioeng
