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The protective role of nutritional antioxidants - including glutathione precursors and direct glutathione supplementation - against impaired redox homeostasis in thyroid pathologies has been highlighted in a comprehensive review in PMC (2023), which confirmed that antioxidant interventions represent a promising adjunct strategy in the management of various thyroid conditions

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Vitamin B6 supports testosterone production by reducing prolactin levels, acting as a cofactor in steroidogenesis enzymes, and modulating androgen receptor sensitivity

NAPQI can be detoxified by subsequent phase II metabolism via conjugation with glutathione (GSH), partly mediated by different glutathione S -transferase (GST) isozymes (Figure 1) (Mitchell et al., 1973b)