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Declarations Funding Work in the authors laboratories was supported in part by National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK102142 (HJ) and R01 DK125465 (AR), as well as by National Institute of General Medical Sciences-funded Liver Disease COBRE grants P20 GM103549 (HJ) and P30 GM118247 (HJ)

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Massage gently onto the face and neck in upward circular motions

For non-clinical laboratory research use only not for human or animal consumption

Oral bioavailability studies in rats show systemic effects even when administered per os, suggesting meaningful absorption through the GI mucosa

Caryophyllene binds to specific receptors in the nervous system, producing sedative and analgesic effects (37), which reduce thyroid-related symptoms in patients