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Clinical Impact and Population-Specific Adaptation of the Ketogenic Diet 6.1

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24: 101978 (read) 2020 Bellande K, Lalo A, Ligat L, Roujol D, Jamet E, Canut H (2020) Recombinant N- glycosylation isoforms of Legume lectins: production and purification from Nicotiana benthamiana leaves following RuBisCO depletion

doi:10.1017/S0033291716002932 81 Pittas, S., Theodoridis, X., Haidich, A.-B., Bozikas, P.-V

The electron transport chain, a series of protein complexes within the mitochondria that produce ATP, becomes inefficient and "leaky." Instead of producing energy, these damaged mitochondria leak excessive amounts of superoxide radicals into the cell, further amplifying oxidative stress

The pathogenesis of ALD involves multiple interconnected aging-related processes, including oxidative stress, inflammation, and mitochondrial dysfunction, all of which are regulated by SIRT1, a key modulator of cellular stress responses (Ramirez et al., 2017)