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Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger

Recent advances in genetic technologies, specifically next-generation sequencing, now allow for the detection of genetic causes of cardiomyopathy in a systematic and unbiased manner

Neurodegenerative diseases like Alzheimer's disease and frontotemporal lobar degeneration are characterized by the abnormal buildup of tau, a protein that damages brain cells and drives cognitive decline

Although it is known that hypermetabolism [203] and accelerated ROS generation [204] are the possible responsible mechanisms by which early exercise causes neuronal loss [205], the beneficial effects of late exercise are probably due to the induction of angiogenesis after the resolution of the acute hypermetabolic environment in early post-stroke

These are later repaired with newly synthesized DNA, substituting the corresponding nucleoside opposite the abasic site, ultimately resulting in the loss of 5mC and passive DNA demethylation (Fig